In summary, obesity represents a significant public health concern on a global scale. The objective of this study is to evaluate the effect of regular consumption of nutritional supplements on body weight and its impact on overweight or obese individuals. The study employed a randomized, placebo-controlled trial design. A randomized, placebo-controlled trial was conducted with male and female participants with a body mass index (BMI) between 25 and 40 kg/m². All subjects underwent a comprehensive six-week weight-loss program, which included an individualized diet devoid of any physical activity recommendations and once-daily consumption of the complex supplement or placebo. The body weight, BMI, and body composition were measured at the beginning and end of the proposed duration (180 days). The results of the study are as follows: A total of 150 participants were randomized, and 120 participants aged 44.16 ± 5.87 years and with a body weight of 80.53 ± 12.51 kg completed the treatment. At the conclusion of the study, there was a discernible trend towards a reduction in body weight, BMI, and waist circumference in the treatment group. Notably, individuals with type III obesity in the experimental group exhibited a significant reduction in body weight (four individuals at the commencement of treatment versus zero individuals at the conclusion of six months) and BMI (25 and 39.9). In contrast, the placebo group did not exhibit any notable changes in their bodies. Conclusions: The regular consumption of the nutritional supplement resulted in a reduction in body weight and BMI in obese individuals after 24 weeks, with the greatest effect observed in those with type III obesity.